•Ä�‘—§Œ’�NŠÂ‹«‰ÈŠwŒ¤‹†�ŠƒWƒƒ�[ƒiƒ‹
EHP 119(7) 2011”N7ŒŽ�† Correspondence
ƒ�ƒ`ƒ‹�…‹â‚̊‹«Œ’�NŒ¤‹†‚ÌŽ¦�´
’Óc•q�G�Aû®“¡‹MŽu�AŒ´“c�³�ƒ

�î•ñŒ¹�FEHP 119(7) Jul 2011 Correspondence
Environmental Health Research Implications of Methylmercury
Toshihide Tsuda, Takashi Yorifuji, Masazumi Harada

Department of Environmental Epidemiology, Okayama University Graduate School of Environmental Science, Okayama, Japan, E-mail: tsudatos@md.okayama-u.ac.jp, Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, Department of Social Welfare Studies, Kumamoto Gakuen University, Kumamoto, Japan

Citation: Tsuda T, Yorifuji T, Harada M 2011. Environmental Health Research Implications of Methylmercury. Environ Health Perspect 119:a284-a284. doi:10.1289/ehp.1103580

Online: 01 July 2011
http://ehp03.niehs.nih.gov/article/fetchArticle.action?articleURI=info%3Adoi%2F10.1289%2Fehp.1103580

T.T. and M.H. have provided expert testimony on Minamata disease.
The other author declares he has no actual or potential competing financial interests.
�iT.T. ‚Æ M.H. ‚Í�A�…–“•a‚ÉŠÖ‚·‚é�ê–副�ØŒ¾‚ð�s‚È‚Á‚½�B
‘¼‚Ì’˜ŽÒ‚Í�AŽÀ�Û‚É–”‚Í�ö�Ý“I‚É�à�­“I—˜ŠQŠÖŒW‚É’ï�G‚µ‚È‚¢‚±‚Æ‚ð�錾‚·‚é�B�j

–ó�FˆÀŠÔ�@•��@�i‰»Šw•¨Ž¿–â‘èŽs–¯Œ¤‹†‰ï�j
http://www.ne.jp/asahi/kagaku/pico/
Œf�Ú“ú�F2011”N7ŒŽ2“ú
‚±‚̃y�[ƒW‚Ö‚ÌƒŠƒ“ƒN�F
http://www.ne.jp/asahi/kagaku/pico/mercury/research/EHP_July_2011_Methylmercury.html


�@�wƒ�ƒ`ƒ‹�…‹â‚Ì—LŠQ‰e‹¿�FŠÂ‹«Œ’�NŒ¤‹†‚ÌŽ¦�´ EHP 118(8) 2010”N8ŒŽ�iAdverse Effects of Methylmercury: Environmental Health Research Implications�j‚Ì’†‚Å�AGrandjean et al. (2010) �i–ó’�1�j�x‚Í�A�…–“•aŽ–Œ�‚Ì—ðŽj‚ðŠÜ‚ñ‚Ń�ƒ`ƒ‹�…‹â”˜˜I‚©‚ç‚à‚½‚炳‚ê‚錒�NƒŠƒXƒN‚̉Ȋw“I”­Œ©‚ðƒŒƒrƒ…�[‚µ‚½�B”Þ“™‚Ì•\‘è‚Í�A�hŒ¤‹†‚ÌŽ¦�´�iresearch implications�j�h‚Å‚ ‚邪�A’˜ŽÒ“™‚ÍŽ–Œ�‚©‚ç‚Ì‚¢‚­‚‚©‚Ì�d—v‚ÈŒx��‚ð“`‚¦‚Ä‚¢‚È‚¢�B

�@‘æˆê‚É�AGrandjean et al. (2010)‚Í�A‚±‚ÌŽ–Œ�‚ª‚ ‚½‚©‚à�h�³Šm‚ÈŒ´ˆö�iƒ�ƒ`ƒ‹�…‹â�j�h‚Ì�³Ž®‚È”F’m‚Ì�d‘å‚È’x‚ꂪ‘Ήž‘[’u‚ð’x‚点‚½‚悤‚É�à–¾‚µ‚Ä‚¢‚é�B‚µ‚©‚µ�A•aˆö•¨Ž¿‚Ì”F’m‚Í—\–h‚ɂƂÁ‚Ä•K—v�ðŒ�‚ł͂Ȃ¢(Goodman et al. 1990)�B‚½‚Æ‚¦•aˆö•¨Ž¿‚ª‚í‚©‚ç‚È‚­‚Ä‚à�A”˜˜IŒ¹‚Æ“`’B‚ª“Á’肳‚ê‚ê‚Î�A‚»‚ê‚ç‚ÍŽæ‚è�œ‚©‚ê‚È‚­‚Ă͂Ȃç‚È‚¢�B�…–“•a‚Ì�ê�‡‚É‚Í�A�Å�‰‚ÌŠ³ŽÒ‚ª“Á’肳‚ꂽ1956”N‚ɂ͂·‚Å‚É�A‰˜�õ‚³‚ꂽŠCŽY•¨‚ð�Û�H‚·‚邱‚Æ‚ª•a‹C‚ÌŒ´ˆö‚Å‚ ‚邱‚Ƃ͔»–¾‚µ‚Ä‚¢‚½�B‚»‚ê‚Í•aˆö•¨Ž¿‚ª“Á’肳‚ê‚é3”N‘O‚Ì‚±‚Ƃł ‚Á‚½(Tsuda et al. 2009)�BGrandjean “™�i2010�j‚Í�AHarada (2004)‚ðˆø—p‚µ‚½‚ª�A”Þ‚ÍŽŸ‚̂悤‚É�‘‚¢‚½�B

�@‚µ‚©‚µ�A“Á’è‚ÌŒ´ˆö•¨Ž¿�i•aˆö•¨Ž¿�j‚ªŒˆ’肳‚ê‚È‚¯‚ê‚΋™Šl‚ð‹ÖŽ~‚·‚é–@“I�ª‹’‚͂Ȃ¢�B�i�H•i‰q�¶–@‘æ2�†‚̉º‚Å‚Í�AŒ´ˆö‚ªŒˆ’肳‚ê‚È‚¢‚Æ‹™Šl‚ð‹ÖŽ~‚·‚邱‚Ƃ͂ł«‚È‚¢�B�j�i–ó’�2�iŽQ�l�j�j

�@‘æ“ñ‚É�AGrandjean et al. (2010)‚Í�Aƒ�ƒ`ƒ‹�…‹â’†“ÅŽ–Œ�‚Ì�h�f’f‚Ì�¢“�h‚ð�q‚ׂĂ¢‚é�B�H’†“łƂµ‚Ä‚Ì�…–“•aŽ–Œ�‚Ì’²�¸‚ÌŒ‡”@‚ª•s•K—v‚È�f’f‚Ì�¢“ï‚ð‚à‚½‚炵‚½�B‚»‚̂悤‚È�¢“‚Í�A’Ê�í�A“ú–{‚É‚¨‚¯‚é�H’†“ÅŽ–Œ�‚Å‚Í�¶‚¶‚È‚¢�B�…–“•a‚Ì�ê�‡‚É‚Í�A1977”N‚É�A“ú–{‚̊‹«�È�iJME�j‚Í�f’fŠî�€‚ðŠm—§‚µ‚½‚ª�A‚»‚ê‚ÍJME‚É‚æ‚Á‚Ä�¥‚¦‚ç‚ꂽ�AˆãŠw“I‚ɂ͒ù�³‚³‚ê‚é‚ׂ«�A�Ç�ó‚Ì‘g‚Ý�‡‚킹‚ð‹�‚ß‚é‚à‚̂ł ‚é�B‚µ‚©‚µŽ–ŽÀ‚Í�AJME‚ÍŠî�€‚ɈãŠw“I�Ø‹’‚ªŒ‡”@‚µ‚Ä‚¢‚邱‚Æ‚ð”F‚߂Ă¢‚½‚Æ‚¢‚¤‚±‚Ƃł ‚é [Committee on Research and Human Rights/Japanese Society and Psychiatry and Neurology (CRHR-JSPN) 2003]�B‚³‚ç‚É�A“ú–{‚̈ãŠwŒ¤‹†ŽÒ‚炪�A‚»‚ÌŠî�€‚͈ãŠw“I‚ÉŠÔˆá‚Á‚Ä‚¢‚邯Žw“E‚µ‚Ä‚¢‚½(CRHR-JSPN 1998)�B�h�f’f‚Ì�¢“�h‚Í‚¨‚»‚ç‚­�A’N‚ª‰e‹¿‚ðŽó‚¯�_ŒoŠw“I’›Œó‚ðŽ�‚Á‚Ä‚¢‚½‚Ì‚©‚ðžB–†‚É‚µ‚½‚Å‚ ‚낤�B

�@‘æŽO‚É�AGrandjean et al. (2010)‚Í�A�h2009”N‚É�A”íŠQŽÒ‚ÌŽc‚è‚̃Oƒ‹�[ƒv‚̂قƂñ‚Ç‚Ì�l�X‚É•â�ž‚ð—^‚¦‚é�iprovide compensation�j‚½‚߂̖@—¥‚ª�§’肳‚ꂽ�h‚Æ�q‚ׂĂ¢‚é�B‚µ‚©‚µ�A‚»‚ê‚Í•â�ž�icompensation�j‚ł͂Ȃ¢�B�…–“•a‚ɂ‚¢‚Ä�A‰e‹¿‚ðŽó‚¯‚½�l�X‚ª�ã�q‚ÌŠî�€‚É‚æ‚Á‚Ä�f’f‚³‚ê‚È‚¯‚ê‚Î�A”Þ“™‚ÍŠ³ŽÒ‚Æ‚µ‚ÄŠ¨’è‚É“ü‚ê‚ç‚ꂸ�A�]‚Á‚Ä“K�؂ɕâ�ž‚³‚ê‚È‚¢�B–ñ2,200�l‚ª�…–“•a‚Æ‚µ‚Ä�f’f‚³‚ê�A•â�ž‚³‚ê‚Ä‚¢‚½‚ª�Aƒ�ƒ`ƒ‹�…‹â’†“Å‚Ì�_ŒoŠw“I�Ç�ó‚Ì“Á’¥‚ðŽ�‚Â�­‚È‚­‚Æ‚à�”–œ�l‚Ì”íŠQŽÒ‚ªŠ³ŽÒ‚Æ‚µ‚Ä”F‚ß‚ç‚ꂸ�A“K�؂ɕâ�ž‚³‚ê‚Ä‚¢‚È‚¢(McCurry 2006)�B

�@‘æŽl‚É�AGrandjean et al. (2010)‚Í�A1959”N‚̃lƒR‚ÌŽÀŒ±‚Ì�A40”N’x‚ê‚Ä”­•\‚³‚ꂽ�h‰ÈŠw“I�d—v�«�h‚ð�q‚ׂĂ¢‚é(Eto et al. 2001)�B‚µ‚©‚µ�A‚±‚Ì•ñ���‘‚Í�A•a—�Šw“I”­Œ©‚¾‚¯‚ð’ñ‹Ÿ‚µ‚Ä‚¨‚è�AƒlƒR‚ÌŽÀŒ±‚Ì�Ú�ׂÈ�à–¾‚Í‚·‚Å‚É1965”N‚É”­•\‚³‚ê‚Ä‚¢‚½(Tomita 1965)�BŒãŽÒ‚Ì‚à‚Ì‚ª—\–h‚ÆŠÇ—�‚Ì‚½‚߂ɂÍ�\•ª‚Å‚ ‚Á‚½‚Å‚ ‚낤�B

�@�ÅŒã‚É�AJME‚ÆŽ©Ž¡‘Ì‚Í�…–“•a‘i�ׂ̔í��‚Å‚ ‚Á‚½‚½‚ß‚É�AJME‚ÆŽ©Ž¡‘Ì‚©‚ç�o‚½Œ¤‹†Ž‘‹à‚Í�A‚±‚Ƃɂæ‚邯—˜‰v‘Š”½�iconflicts of interest�j‚ðˆø‚«‹N‚±‚µ�AŒ¤‹†ŽÒ‚̑ԓx‚ɉe‹¿‚ð—^‚¦‚½‚©‚à‚µ‚ê‚È‚¢�B


References

CRHR-JSPN (Committee on Research and Human Rights/Japanese Society and Psychiatry and Neurology) 1998. An opinion on the criteria on acquired Minamata disease Psychiatr Neurol Jpn 100:765?790. Find this article online

CRHR-JSPN (Committee on Research and Human Rights/Japanese Society and Psychiatry and Neurology). 2003. An opinion about Minamata disease accreditation system and medical specialists�f involvement [in Japanese]. Psychiatr Neurol Jpn105:809?834.

Eto K, Yasutake A, Nakano A, Akagi H, Tokunaga H, Kojima T.. 2001. Reappraisal of the historic 1959 cat experiment in Minamata by the Chisso factory. Tohoku J Exp Med 194(4):197?203. Find this article online

Goodman RA, Buehler JW, Koplan JP. 1990. The epidemiologic field investigation: science and judgment in public health practice. Am J Epidemiol 132:91?96. Find this article online

Grandjean P, Satoh H, Murata K, Eto K.. 2010. Adverse effects of methylmercury: envionmental health research implications. Environ Health Perspect 118:1137?1145. Find this article online

Harada M. 2004. Minamata Disease (Sachie T, George TS, translators). Tokyo:Iwanami Shoten.

McCurry J.. 2006. Japan remembers Minamata. Lancet 367:99?100. Find this article online

Tomita H.. 1965. Minamata disease 12 Goka 7:346?353. Find this article online Tsuda T, Yorifuji T, Takao S, Miyai M, Babazono A.. 2009. Minamata disease: catastrophic poisoning due to a failed public health response. J Public Health Policy 30:54?67. Find this article online


–ó’�1
EHP 118(8) 2010”N8ŒŽ�†�@ƒ�ƒ`ƒ‹�…‹â‚Ì—LŠQ‰e‹¿�FŠÂ‹«Œ’�NŒ¤‹†‚ÌŽ¦�´
http://www.ne.jp/asahi/kagaku/pico/mercury/research/EHP_Aug_2010_Methylmercury_Lessons_Learned.html

EHP_118(8)_Aug_2010 Adverse Effects of Methylmercury: Environmental Health Research Implications
http://ehp03.niehs.nih.gov/article/fetchArticle.action?articleURI=info%3Adoi%2F10.1289%2Fehp.0901757

–ó’�2�iŽQ�l�j
�‘—§�…–“•a‘��‡Œ¤‹†ƒZƒ“ƒ^�[
�u�…–“•a‚ÉŠÖ‚·‚éŽÐ‰ï‰ÈŠw“IŒ¤‹†‰ï�v•ñ���‘
�…–“•a‚̔ߌ€‚ðŒJ‚è•Ô‚³‚È‚¢‚½‚ß‚É
�|�…–“•a‚ÌŒoŒ±‚©‚çŠw‚Ô‚à‚Ì�|
•½�¬11”N12ŒŽ�@�…–“•a‚ÉŠÖ‚·‚éŽÐ‰ï‰ÈŠw“IŒ¤‹†‰ï

‘æ2�Í�@�…–“•a‚ÌŒ´ˆö‹†–¾‹y‚Ñ”­�¶Œ¹Šm’è‚̉ߒö�i‚»‚Ì1�j�iPDF”Å33ƒy�[ƒW�j http://www.nimd.go.jp/syakai/webversion/pdfversion/028041_2shou.pdf

�u�E�E�EŒ§‰q�¶•”‚Í�A�H•i‰q�¶–@‘æ4�ð‘æ2�†‚Ì‹K’è‚É�€‚¶‚½�󋵂ł ‚邯”»’f‚µ�A•ߊl‚â�Û�H‚ð‹Ö‚¶‚é’mŽ–��ަ‚ð�o‚·‚Æ‚¢‚¤•û�j‚ðŒˆ‚ß�A“¯”N8ŒŽ16“ú�AŒú�¶�È‚É�H•i‰q�¶–@‚Ì“K—p‚̉”ۂð�Ɖ‚½�B
�@‚Æ‚±‚낪�A“¯”N9ŒŽ11“ú�AŒú�¶�ÈŒö�O‰q�¶‹Ç’·‚©‚çŒF–{Œ§’mŽ–‚ɓ͂¢‚½‰ñ“š‚Í�A�u�…–“˜p“Á’è’nˆæ‚Ì‹›‰î—Þ‚ð�Û�H‚·‚邱‚Æ‚Í�AŒ´ˆö•s–¾‚Ì’†�•�«�_Œo޾г‚ð”­�¶‚³‚¹‚邨‚»‚ꂪ‚ ‚é‚Ì‚Å�A�¡Œã‚Æ‚à�…–“˜p‚Ì‹›‰î—Þ‚ª�ێ悳‚ê‚È‚¢‚悤Žw“±‚·‚邱‚Æ�B‘R‚µ�A�…–“˜p“à“Á’è’nˆæ‚Ì‹›‰î—Þ‚Ì‚·‚ׂĂª—L“ʼn»‚µ‚Ä‚¢‚邯‚¢‚¤–¾‚ç‚©‚È�ª‹’‚ª”F‚ß‚ç‚ê‚È‚¢‚Ì‚Å�A“–ŠY“Á’è’nˆæ‚ɂċ™Šl‚³‚ꂽ‹›‰î—Þ‚Ì‚·‚ׂĂɑ΂µ�H•i‰q�¶–@‘æ4�ð‘æ2�†‚ð“K—p‚·‚邱‚Ƃ͂ł«‚È‚¢‚à‚Ì‚Æ�l‚¦‚é�v‚Æ‚¢‚¤‚à‚̂ł ‚Á‚½�B�E�E�E�v



‰»Šw•¨Ž¿–â‘èŽs–¯Œ¤‹†‰ï
ƒgƒbƒvƒy�[ƒW‚É–ß‚é